Keeping to much artifact turn on will slow down performance due to fact that the host will have too much information to move from one database to another one, there is a reason that turning global tracking off is one of the most efficient ways to improve performance for you BizTalk environment.
The more you are tracking the more data will fill up your databases, the TrackingData tables in the messagebox contains information that are supposed to be moved to the tracking database, and the tracking database itself contains numerous tables with information regarding all the artifacts you have tracked. This will increase the sizes of your databases and you will end up with large databases.
My professional recommendation regarding artifact tracking is to turn it completely off in any production environment. This will lower the load of your BizTalk databases and make sure that the BizTalkDTADb won’t grow enormous.
Applications shouldn't be tested in production environments, the reasons are numerous. Artifacts like ports and orchestrations that are intended for testing should be removed from the application before you take them into the production environment. Not only that applications should never be tested in production, even though the system you are testing the application for don't have a valid test environment you should install the application in test, test it and move it to production and making sure any "test" ports or other artifacts should be deleted.
The recommendation is to keep test and production separate, keep all artifacts that are designed for test out of the applications in production, by this i mean test copy ports etc.
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